Table 1.
Mean (SEM) of Acb neurons exhibiting phasic cell firing relative to the water—but not cocaine-reinforced response during stable self-administration behavior on the multiple schedule
|
|
Type PR (n = 7) |
Type RFe (n = 6) |
Type RFi (n = 9) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Epoch (sec)
|
Water
|
Cocaine
|
Water
|
Cocaine
|
Water
|
Cocaine
|
|||
| Baseline | |||||||||
| −10 to −7.5 | 3.76 (0.49) | 3.13 (0.52) | 1.37 (0.14) | 0.60 (0.08) | 3.03 (0.33) | 0.99 (0.10) | |||
| Response | |||||||||
| −2.5 to 0 | 6.06 (0.77)a | 3.43 (0.48) | 0.98 (0.09) | 0.51 (0.06) | 1.59 (0.15) | 0.88 (0.08) | |||
| Reinforcement | |||||||||
| 0-2.5 | 3.50 (0.48) | 4.14 (0.56) | 2.59 (0.10)a | 0.60 (0.09) | 1.08 (0.12)a | 0.80 (0.08) | |||
| Recovery | |||||||||
| 7.5-10
|
3.34 (0.55)
|
3.52 (0.56)
|
2.54 (0.27)
|
0.57 (0.10)
|
2.94 (0.33)
|
0.90 (0.09)
|
|||
a
Forty percent change compared with baseline within the same column; significant difference (p < 0.05) compared with baseline within the same column.