Table 2.
Mean (SEM) of Acb neurons exhibiting phasic cell firing relative to the cocaine—but not water-reinforced response during stable self-administration behavior on the multiple schedule
|
|
Type PR (n = 9) |
Type RFe (n = 4) |
Type RFi (n = 5) |
Type PR + RF (n = 2) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epoch (sec)
|
Water
|
Cocaine
|
Water
|
Cocaine
|
Water
|
Cocaine
|
Water
|
Cocaine
|
||||
| Baseline | ||||||||||||
| −10 to −7.5 | 2.09 (0.18) | 3.12 (0.32) | 0.65 (0.20) | 1.03 (0.10) | 1.62 (0.22) | 1.17 (0.20) | 3.98 (2.31) | 2.23 (1.27) | ||||
| Response | ||||||||||||
| −2.5 to 0 | 1.78 (0.18) | 5.52 (0.52)a | 0.90 (0.15) | 1.12 (0.16) | 1.63 (0.13) | 0.76 (0.12) | 3.46 (1.95) | 4.19 (1.99)a | ||||
| Reinforcement | ||||||||||||
| 0-2.5 | 1.36 (0.17) | 2.31 (0.24) | 0.76 (0.13) | 2.09 (0.18)a | 1.23 (0.14) | 0.30 (0.05)a | 4.16 (2.25) | 6.50 (0.16)a | ||||
| Recovery | ||||||||||||
| 7.5-10
|
1.44 (0.13)
|
1.94 (0.23)
|
0.75 (0.17)
|
1.18 (0.11)
|
1.02 (0.15)
|
0.57 (0.09)
|
3.56 (2.06)
|
3.38 (0.38)
|
||||
a
Forty percent change compared with baseline within the same column; significant difference (p < 0.05) compared with baseline within the same column.