Figure 7.
Effects of 8-OH-DPAT on SCI-induced respiratory dysfunction at 24 hr in animals treated with the 5-HT1A receptor antagonist p-MPPI. Twenty-four hours after SCI, animals exhibited decreased Vt (A), increased f (B), and decreased Ve (C) with room air breathing conditions as well as a reduced response to 7% CO2. Treatment with p-MPPI (3 mg/kg, i.p.) followed by 8-OH-DPAT (250 μg/kg, i.p.) blocked the normalization of respiration previously seen with 8-OH-DPAT (Fig. 2). Data reported are means ± SEM for three rats and were analyzed by one-way ANOVA followed by Tukey's and Dunn's tests. *Significant difference from preinjury value obtained with the same breathing condition (room air or 7% CO2); #significant difference compared with values obtained breathing room air.