Figure 8.

Proposed correlation between hypoxia and the regulation of cordycepin biosynthesis in liquid surface culture of Cordyceps militaris. Hypoxic conditions induced the activation of siderophores to take up the iron for heme biosynthesis. Simultaneously, the conditions also activated the ergosterol biosynthesis, which is also induced by siderophores. The C6 transcription factor Zn (2)‐Cys (6) (CCM_07141) regulated the ergosterol biosynthesis and heme biosynthesis and the iron cluster genes of cordycepin biosynthesis that might be partially regulated by the C6 transcription factors (TFs) (CCM_07141). Finally, the presence of cordycepin suggested the inhibition of the C6 TFs and the cluster genes of cordycepin biosynthesis