Figure 10.

Block of type II metabotropic glutamate receptors modified short-term plasticity at recurrent mossy fiber synapses in response to a 2 Hz stimulus train. Values are means ± SEM for 10 cells in each group. Top, LY 341495 (100 nm) reduced and eventually abolished response depression observed when the NMDA receptor-mediated EPSC was isolated with 30 μm bicuculline and 10 μm NBQX [p < 0.001 by Newman–Keuls test after two-way ANOVA (treatment × stimulus number)]. Bottom, When the NMDA receptor-mediated component was isolated with 30 μm bicuculline and 40 μm SYM 2206, facilitation usually appeared earlier in the train during application of LY 341495. However, this effect was not statistically significant [p > 0.1, two-way ANOVA (treatment × stimulus number)].