Figure 7.

Block of type II metabotropic glutamate receptors enhanced the frequency-dependent reduction in response failures during minimal electrical stimulation. Recordings were made in the absence and then in the presence of bath-applied 100 nm LY 341495. A, LY 341495 did not affect the percentage of response failures during stimulation at a frequency of 0.2 Hz but reduced the percentage of failures during 2 and 10 Hz stimulus trains. Values are means ± SEM for nine cells. ^*p < 0.05 by paired t test. B, Analysis of failure rates at different times during the stimulus train suggested no obvious time or use dependence in the action of LY 341495; its onset of action must have occurred within the first 10 stimuli. For other details, see Figure 4.