Table 3.
Genes that are upregulated in both amyloid-containing brain regions and amyloid-free brain regions of transgenic mice (array and qRT-PCR data)
|
|
Array data Percentage of nontransgenic mean ± SEM |
qRT-PCR data Percentage of nontransgenic mean ± SEM |
||||
|---|---|---|---|---|---|---|
| Marker RNA
|
Amyloid-containing area
|
Amyloid-free area
|
Amyloid-containing area
|
Amyloid-free area
|
||
| Transgene | ||||||
| APP | 192 ± 7 (4.8) | 209 ± 7 (5.7) | ND | ND | ||
| Prion protein (UTR) | 223 ± 15 (6.4) | 242 ± 14 (7.3) | ND | ND | ||
| Inflammation | ||||||
| Apolipoprotein E | 160 ± 4 (3.2) | 171 ± 10 (3.8) | 156 ± 16 | ND | ||
| α-1 type III collagen | 162 ± 7 (3.3) | 167 ± 12 (3.6) | ND | ND | ||
| Complement component C1q α chain | 289 ± 27* (9.7) | 182 ± 18* (4.3) | ND | ND | ||
| Complement component C4 | 297 ± 22* (10.1) | 154 ± 8* (2.9) | ND | ND | ||
| Cystathionine β-synthase | 377 ± 22* (14.1) | 194 ± 16* (4.9) | ND | ND | ||
| GFAP | 483 ± 64* (19.4) | 182 ± 13* (4.3) | 629 ± 115 | ND | ||
| Thyroid hormone receptor α | 618 ± 73* (26.1) | 234 ± 24* (6.9) | ND | ND | ||
|
Tyrosine kinase binding protein
|
254 ± 6* (7.9)
|
161 ± 7* (3.3)
|
ND
|
ND
|
||
*
Data in bold are significantly more highly expressed in amyloid-containing regions than amyloid-free regions of transgenic mice. ND, Not determined.