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. 2003 Jun 15;23(12):5295–5301. doi: 10.1523/JNEUROSCI.23-12-05295.2003

Figure 1.

Figure 1.

Measurement of depression-like behaviors in forced swim test. A, Both male and female mutant (Mut) mice showed increased immobile time during 5 min forced swim compared with wild-type (Wt) mice (n = 10). Overall, females showed significantly greater immobile time compared with their respective males of the same genotype. *p < 0.05 compared with wild-type males; **p < 0.01 compared with wild-type males; ***p < 0.001 compared with wild-type females and male mutant mice; ANOVA and Fisher's post hoc test. B, Both male and female mutant mice demonstrated decreased swim time compared with wild-type littermates (n = 10). *p < 0.05 compared with wild-type males; **p < 0.01 compared with wild-type females; ***p < 0.001 compared with wild-type males; ANOVA and Fisher's post hoc test. C, Female mice deficient for CRFR2 spent significantly less time climbing during the forced swim test compared with female wild-type littermates;***p < 0.001;ANOVA and Fisher'spost hoc test.