Figure 9.
Simulations of the dependence of spontaneous firing on resurgent sodium current kinetics. A, Simulated spontaneous firing rate as a function of sodium current amplitude for the model with wild-type (filled symbols) and med-like (open symbols) sodium current kinetics. The x value of 1 corresponds to the modeled GNa that replicates the mean current amplitudes recorded from wild-type cells. GNa was increased in the med-like model to produce a peak transient sodium current during depolarization to 0 mV that was the same as the wild-type model. B, Spontaneous firing rate simulated with the wild-type (filled symbols) and med-like (open symbols) sodium current kinetics, as a function of the parameter controlling the V1/2 of the highly TEA-sensitive current, Kfast. This parameter does not correspond directly to the experimental V1/2. The value simulating the wild-type experimental mean V1/2 is indicated with a vertical dashed line. C, Simulated firing after equilibration at -70 mV with wild-type (left) and med-like sodium currents (right), with input resistances similar to wild-type (top) or med (bottom) cells.