Figure 7.

Simulations of sodium currents in wild-type and med Purkinje neurons. In all panels, currents are offset for clarity. A, Experimental records of TTX-sensitive sodium currents elicited by step depolarizations (top traces) and step repolarizations (bottom traces) to -30 mV for wild-type and med cells. Resurgent current is visible in the wild-type trace as a slowly rising, slowly decaying current evoked during repolarization. B, Simulations of sodium currents evoked by voltage protocols as in A. Currents were generated by four variants of the kinetic model of Raman and Bean (2001), as indicated. Arrowheads in bottom panel indicate the time of the repolarizing step.