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. 2003 Jul 2;23(13):5634–5644. doi: 10.1523/JNEUROSCI.23-13-05634.2003

Figure 5.

Figure 5.

Requirement of mGlu5 receptor activation for bicuculline induced persistent bursting activity. A, Examples of bursts in the CA3 region of slices from mGluR5-KO (left) and wild-type (right) mice. Top and middle traces represent simultaneous extracellular and intracellular recordings, respectively. Insets below show respective bursts on an expanded time scale. B, Bicuculline (BIC; 20 μm) applied during the period indicated by the gray bar did not induce persistent bursting activity in slices of either mGluR5-KO mice (left graph; n = 15 slices) or wild-type mice treated with MPEP (50 μm; right graph, black bar; n = 12 slices).