Figure 5.

Summary demonstrating that the light-reared LTD phenotype can be mimicked either by partially blocking NMDA receptor function in dark-reared visual cortex or by briefly exposing dark-reared animals to light (a procedure known to shorten NMDA receptor currents). A, The magnitude of synaptic depression induced by 0.5 or 1 Hz stimulation in dark-reared cortex can be reproduced across experiments. B, Summary graphs demonstrating the average magnitude (±SEM) of synaptic depression induced by 0.5 or 1 Hz stimulation in dark-reared (DR) cortex, APV-treated DR cortex (DR + APV), light-exposed DR cortex (DR + LE), and light-reared (LR) cortex. Dark-reared values represent averaged data across all three experiments.