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. 2003 Jul 2;23(13):5507–5519. doi: 10.1523/JNEUROSCI.23-13-05507.2003

Figure 6.

Figure 6.

smu/smoh and ace/fgf8 double mutants develop additive DA neuronal phenotypes. A, C, E, G, dat expression or th expression (B, D, F, H). A–H, Lateral views, anterior to the left, dorsal is to the top. In smu/smoh (C), ace/fgf8 (E), and smu ace (G) double mutants, the earliest developing dopaminergic neurons in the ventral diencephalon appear normal when compared with wild-type embryos (A). By 48 hpf, additive phenotypes are observed in smu ace double mutants (H); the ventral diencephalic cluster is misshapen as in smu mutants (D) and the LC is absent as in ace (F). Insets in B, D, F, and H show higher magnification views of the region of the locus coeruleus. vDD, Ventral diencephalic dopaminergic neurons. White arrows indicate the absence of the LC.