Table 1.

Effects of hedgehog, FGF8, and Nodal pathway mutants on the formation of the main dopaminergic and noradrenergic groups in the zebrafish CNS

	Nodal signaling							Hh signaling			Hh plus FGF8	MHB organizer-FGF8
	MZsur	Zsur	oep	cyc	syu	smu	smu/ace	ace	spg	noi	ace/no
Ventral diencephalic DA neurons
24 hpf	-	(+)	(o)	(o)	+	+	+	+	(+)	+	(+)
48 hpf	-	(-)	(o)	(o)	#/-	#	#	-	(+)	-	(-)
72 hpf	N.D.	-	o	o	#/-	#/-	N.D.	+	-	+	(-)
Pretectal CA neurons
72 hpf	N.D.	+	o	o	-/o	-/o	N.D.	+	(+)	+	(+)
Locus coeruleus CA neurons
48 hpf	N.D.	+	(+)	(+)	(+)	(+)	o	o	(o)	o	(o)
72 hpf	N.D.	+	+	+	(+)	(+)	N.D.	o	o	o	(o)
Medulla oblongata CA neurons
48 hpf	N.D.	(+)	(+)	(+)	(+)	(+)	(+)	+	(+)	+	(+)
72 hpf	N.D.	(+)	+	+	(+)	(+)	N.D.	+	+	+	(+)
Amacrine DA neurons
72 hpf	N.D.	(+)	+	o	-/o	-/o	N.D.	+	(+)	N.D.	N.D.
Olfactory bulb CA neurons
72 hpf	N.D.	+	o	-/o	+	+	N.D.	+	+	+	+

+, Not affected; -, reduced; o, absent; -/o, highly reduced or absent; #, altered morphology of the neuronal cluster; N.D., not determined; symbols in brackets, data not shown in figures; hpf, hours postfertilization.