Implementation of nonlinear synaptic activity in local circuits within the SGI. A, Schematic illustration of a recording from a neuron in a small rectangular piece punched out from the SGI. Stim., Stimulating electrode; Rec., recording electrode. B, Synaptic response to stimulation within this piece in control solution. Five traces are superimposed. C, Synaptic response to stimulation within the piece of SGI in the presence of 10 μm Bic. D, Relationship between number of action potentials and stimulus strength in the presence of Bic. Filled circles and error bars represent mean and SEM, respectively.