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. 2003 Jul 2;23(13):5531–5535. doi: 10.1523/JNEUROSCI.23-13-05531.2003

Figure 2.

Figure 2.

Effect of secretase inhibition on cell viability. A, Incubation for 24 hr with γ- or β-secretase inhibitors on the viability of cortical neurons (n = 9 for each condition). B, Time dependence of γ-IV toxicity on cortical cultures compared with vehicle-treated controls. Values are the mean of four experiments for each time point. C, Effect of 24 hr incubation with secretase inhibitors on cell death in cerebellar granule neurons (open bars; n = 9), the SH-SY5Y cell line (hatched bars; n=9), and rat astrocytes cultures (filled bars; n = 9). D, Effect of 48 hr incubation with secretase inhibitors on the viability of non-neuronal cell lines DDT1-FM2 (open bars; n = 4), HEK293 (hatched bars; n = 4), and human teratorhabdoid tumor cells (filled bars; n=4). γ-IX, γ-secretase inhibitor.