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Structural requirement for vitamin K-dependent protection against cystine depletion-induced cell death. A, Structures of vitamin K1, K2, and compounds tested in B for their effects on cystine depletion-induced OL death. B, Effect of various compounds on OL cell death induced by cystine depletion. Representative results of two to three independent experiments are shown. No cytotoxicity to OLs in normal culture medium was seen with the test compounds at the concentration used.
