Table 2.

The five phases of danger control

	Clotting	Inflammation	Epithelial healing	Mesenchymal healing	Fibrolysis
Time scale	Minutes	Hours to days	Days to weeks	Weeks to months	Months
Danger to control	Bleeding	Sepsis	Chronic inflammation	Tissue instability	Fibrosis
Macrophage contribution	Secretion of tissue factor promotes coagulation	Pathogen killing, secretion of proinflammatory mediators	Secretion of anti-inflammatory mediators/ growth factors	Secretion of profibrotic mediators	Protease secretion and ECM clearance
Side effects	Vascular disease	Collateral tissue damage	Epithelial hyperplasia	Fibrosis/sclerosis	Tissue instability?