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Potential enhancing effect of HIV-1 Nef, HCV Core and TRAF (2, 5, 6) on HIV-1 replication in MDMs. TRAF2, TRAF5 and TRAF6 interact with HIV-1 Nef, HCV Core interacts with TRAF2 and TRAF5, and HIV-1 Nef interacts with HCV Core. The TRAF (2, 5, 6) activation mediated by HIV-1 Nef and HCV Core enhances NF-κB activation and increases HIV-1 replication in MDMs, and could be a critical factor for optimal replication of HIV-1 in MDMs of HIV-HCV-coinfected patients.
