Table 3.
Results of PCR array mouse innate and adaptive immune responses
| Gene | x-fold of control |
|
|---|---|---|
| CRAMP-WT | CRAMP-KO | |
| Adora2a (adenosine A2A receptor) | 5.5895 | 4.4838 |
| Casp1 (caspase-1) | 4.3058 | 4.314* |
| Casp 4 (caspase-4) | 22.9138 | 38.8959* |
| Ccl2 (CCL2) | 106.4495 | 2,875.7481 |
| Ccr3 (C-C chemokine receptor type 3) | – | 4.0441 |
| Cd14 | 34.4855 | 29.3627 |
| Clec7a (C-type lectin domain family 7 member A/dectin) | – | 5.7234* |
| Cybb (cytochrome b-245) | 14.0473 | 29.3954* |
| Defb4 | – | 4.1689 |
| Dmbt1 (deleted in malignant brain tumors 1) | – | 4.0212 |
| Hmox1 [heme oxygenase (decycling) 1] | 5.4103 | 5.4396 |
| Ifnb1 (interferon-β1) | 9.1583 | 4.0817 |
| Il10 (IL-10) | 4.4772 | 4.7127 |
| Il1a (IL-1α) | 11.614 | 14.019 |
| Il1b (IL-1β) | 52.6794 | 66.8595 |
| Il1f9 (IL-1 family member 9) | 24.1392 | 25.3921 |
| Il1r2 (IL-1 receptor, type II) | 8.5841 | 6.4109 |
| Il1rn (IL-1 receptor antagonist) | 6.6392 | 9.6017 |
| Il6 (IL-6) | 55.0987 | 48.4762 |
| Irf1 (interferon regulatory factor 1) | 6.3225 | 12.0827* |
| Lyz1 (lysozyme 1) | 5.4183 | 13.1175 |
| Myd88 [myeloid differentiation primary response gene (88)] | - | 6.5557* |
| Ncf4 (neutrophil cytosolic factor 4) | 5.3611 | 9.4759* |
| Nfkbia [nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha (http://www.genenames.org/data/hgnc_data.php?hgnc_id=7797)] | 4.1035 | |
| Nlrc4 (NLR family CARD domain-containing protein 4) | – | 5.5342* |
| Pglyrp1 (peptidoglycan recognition protein 1) | – | 4.5003* |
| Pglyrp3 (peptidoglycan recognition protein 3) | 4.4648 | – |
| Ptafr (platelet-activating factor receptor gene) | – | 11.5002* |
| Serpine1 (plasminogen activator inhibitor-1) | 18.6022 | 23.5001* |
| Tlr1 (TLR1) | – | 5.0086* |
| Tlr2 (TLR2) | 7.9732 | 26.2452 |
| Tlr8 (TLR8) | – | 6.2569* |
| Tlr9 (TLR9) | – | 4.1669 |
| Tnf (TNF-α) | 25.0953 | 82.921 |
| Trem1 (triggering receptor expressed on myeloid cells 1) | 7.759 | 8.4433 |
| Fn1 (fibronection 1) | –18.7371 | – |
| Ifngr2 (interferon-γ receptor 2) | –33.3823 | – |
| Nos2 (nitric oxide synthase 2) | –13.9407 | – |
| Serpina1a [serine (or cysteine) peptidase inhibitor member 1A] | – | –4.5967 |
Expression levels of different genes in the hippocampal formation of CRAMP-KO and -WT mice. Only genes with increased or decreased expression rates are listed. – = No change in expression. Each group represents the analysis of 3 mice. Data are presented as means. * p < 0.05 vs. noninfected controls (t test).