Fig. 1.

Neutrophil recruitment in response to LPS is reduced in Ccr5^−/− and Fpr1^−/− mice. Mice were challenged with LPS by inhalation and sacrificed 4 h later. The quantifications of alveolar (a), interstitial (b) and intravascular (c) neutrophils within the lungs of WT Ccr2^−/−, Ccr5^−/−, Fpr1^−/− and Fpr2^−/− mice are displayed. n = 8-10 for each bar. d Microvascular permeability was assessed by measurement of FITC-dextran clearance. Structural analyses of histological lung sections were made based on HE staining (e, f). Scale bar = 100 µm. Statistical significance was tested using one-way analysis of variance with Dunnett's post hoc test. Asterisk indicates significant difference compared with LPS-treated WT mice.