Fig. 1.

Immunomodulatory functions of type III IFN. IFN-λR is expressed in DCs, T cells, and NK cells. DCs can produce IFN-λs in response to the stimulation of TLRs, and IFN-λs can also affect DCs, resulting in the change of MHC, CCR7, and costimulatory molecules. IFN-λs-DCs or IFN-λs themselves can influence the function of T cells, including promotion of Th1, inhibition of Th2, activation of Mo/Mø, and changing the proportion of Treg and the cytotoxicity of CD8+ T cells. Cross marks = IFN-λs could not work directly on this kind of cells; question marks = the pathway was not completely confirmed; green color = promote; red color = inhibit.