Table 2.

IFN-λs and relevant diseases

Subtype	Experimental system	Effect and possible mechanism	References
λ1, λ2/3	antitumor function in mice	regulate innate and adaptive immune responses of NK, T cells, and DCs, and antiangiogenesis	50, 67–69, 79, 80
λ1, λ2/3	asthma	modulate lung DC function to promote Th1 immune skewing and suppress allergic airway disease, and decreased IFN-λ production correlating with severity of rhinovirus-induced asthma exacerbation and virus load	18, 19, 61, 83, 84, 90
λ2	Con A-induced hepatitis	induce Th1 cytokine production and T cell-mediated liver injury	96
λ1, λ2/3	SLE	significantly enhanced in patients with SLE, and stimulate the production of CXCL10 (IP-10), CXCL9 (MIG), and IL-8	92–94
λ	food allergy	controversial: induced apoptosis of T cells or intestinal epithelial cells, and suppressed or induced antigen-specific Th2 cell-mediated inflammation	73, 95