Fig. 4.
NOX2-deficient mice display more severe symptoms of systemic inflammation. A total 24-hour inflammation score (a) was generated by scoring saline- and zymosan-injected mice for symptoms of systemic inflammation including lethargy (b), ruffled fur (c), conjunctivitis (d), and diarrhea (e) 24 h after injection. Each dot represents a single mouse with means indicated by horizontal lines (n = 6 WT saline, n = 20 WT zymosan, n = 7 gp91phox-/y saline, and n = 19 gp91phox-/y zymosan from 3 independent experiments). * p < 0.05; ** p < 0.01; *** p < 0.001.