Table 1.

Summary of glycosidases and their characteristics described in this review

Glyco-sidase	Organism	Glycoside hydrolase familya	Endoglycosidase or exoglycosidase activity	Specificity	Known glycoprotein substrate(s)	Reference
EndoS	S. pyogenes	GH 18	endo	biantennary N-linked glycan on IgG	IgG	[23]
EndoS49	S. pyogenes	GH 18	endo	biantennary N-linked glycan on IgG	IgG	unpublished
EndoC	group C streptococci	GH 18	endo	biantennary N-linked glycan on IgG	IgG	unpublished
NanA	S. pneumoniae	GH 33	exo	sialic acid α2–3 or α2–6 linked to galactose	IgA1, hLF, hSC, α1-acid glycoprotein	[17, 33, 36]
BgaA	S. pneumoniae	GH 2	exo	galactose (β1–4 linked to N-acetylglucosamine	IgA1, hLF, hSC, α1-acid glycoprotein	[17, 34, 36]
StrH	S. pneumoniae	GH 20	exo	N-acetylglucosamine β1 linked to mannose	IgA1, hLF, hSC, α1-acid glycoprotein	[17, 35, 36]
EndoD	S. pneumoniae	GH 85	endo	Complex N-linked glycans	TF, fetuin, IgG	[40, 41]
EngSP	S. pneumoniae	GH 101	endo	core-1 O-linked glycans	fetuin	[44, 45]
EndoE	E. faecalis	GH 18 (α-domain), GH 20 (β-domain)	endo	biantennary and high mannose N-linked glycan (α-domain), biantennary N-linked glycan on IgG (β-domain)	RNaseB, hLF, IgG	[53], unpublished
EngEF	E. faecalis	GH 101	endo	core-1 and core-3 O-linked glycans	unknown	[44]
PPA1560	P. acnes	GH 33	exo	unknown	unknown	–
EngPA	P. acnes	GH 101	endo	core-1 and core-3 O-linked glycans	unknown	[44]
EndoF1	E. meningosepticab	GH 18	endo	high mannose, hybrid type N-linked glycans	several denatured glycoproteins	[58]
EndoF2	E. meningosepticab	GH 18	endo	complex biantennary N-linked glycans	several denatured glycoproteins	[71]
EndoF3	E. meningosepticab	GH 18	endo	complex bi- and triantennary N-linked glycans	several denatured glycoproteins	[71]
SiaC	C. canimorsus	GH 33	exo	Unknown	IgG, fetuin	[49]
GpdG	C. canimorsus	GH 18	endo	complex N-linked glycans	IgG, fetuin	[49]
NanH	V. cholerae	GH 33	exo	sialic acid from higher-order gangliosides	GM1 ganglioside	[65]

^aAccording to the classification of CAZY (http://www.cazy.org/Glycoside-Hydrolases.html). ^b Formerly known as Flavobacterium meningosepticum. TF = Transferrin, hSC = human secretory component, hLF = human lactoferrin.