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. 2019 May 28;20(9):1249–1257. doi: 10.1080/15384047.2019.1617569

Figure 1.

Figure 1.

LINC00511 is upregulated in thyroid carcinoma and its silencing promotes radiosensitivity of thyroid carcinoma cells. (A) The expression level of LINC00511 in thyroid carcinoma cell lines (TPC-1, BCPAP and IHH-4) and normal thyroid epithelial cell line (Nthy-ori 3–1) was measured by qRT-PCR. (B) qRT-PCR analysis of LINC00511 expression in TPC-1 and BCPAP cells under 4Gy irradiation. (C) qRT-PCR was used again to examine the expression level of LINC00511 in TPC-1 and BCPAP cells treated with sh-NC, sh-LINC00511#1 or LINC00511#2. (D) Cell proliferation of TPC-1 and BCPAP cells with the silencing of LINC00511 under 0 or 4Gy irradiation was, respectively, tested by CCK-8 assay. (E) Colony formation result of sh-LINC00511#1-transfected TPC-1 and BCPAP cells at the indicated irradiation of 0, 2, 4, 6 or 8Gy. (F) Under 0 or 4Gy irradiation, cell apoptosis rates of TPC-1 and BCPAP cells with the treatment of sh-LINC00511#1 were individually assessed by flow cytometry. (G) Western blot analysis of PARP levels in sh-LINC00511#1-treated TPC-1 and BCPAP cells with 0 or 4Gy radiation. *P < .05, **P < .01.