A. GRHL2 knockdown promoted invasion and migration ability of HCT116 cells. B. Wound healing assay demonstrated the promotive effect migration ability of GRHL2-knockdown. *relative to Vector/Scr-con control cells, *p < 0.05, ** p < 0.01, p < 0.001. #relative to Parental control cells, #p < 0.05, ##p < 0.01, ###p < 0.001.