Fig. 1.

a Treatment with LL-37 for 24 h reduces the MG63 osteoblast cell number in a concentration-dependent manner. LL-37 at 4 and 8 µM reduces the osteoblast cell number by 40 and 75%, respectively, while lower concentrations of LL-37 lack an effect. b Treatment with 4 µM LL-37 for 1 and 3 days reduces the MG63 cell number by about 40%. A lower concentration (0.1 µM) of LL-37 has no effect on the cell number neither at 1 nor 3 days of treatment. Values are means ± SEM of 4-15 observations in each group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. controls.