Table 4.
The classification of PRMTs inhibitors based on the binding site
| Inhibitor class | Inhibitor binding | PDB entry | PRMT type |
|---|---|---|---|
| Class I | Ado-Met pocket | 5IS8 | PRMT3 |
| 5ISH, 5TBH | PRMT4 | ||
| 5FA5, 6CKC | PRMT5 | ||
| 4C04 | PRMT6 | ||
| Class II | Substrate arginine pocket | 5E8R | PRMT1 |
| 5U4X, 5ISI, 5LGS | PRMT4 | ||
| 4Y2H, 4Y30, 5EGS | PRMT6 | ||
| Class III | AdoMet/arginine substrate pocket | 5IS9, 5ISB, 5ISC, 5ISD, 5ISE, 5ISF, 5ISG, 5K8V, 5K8W, 5LV2, 5LV3, 5TBI, 5TBJ | PRMT4 |
| 5K8X, 5LV4, 5LV5, 4QQK | PRMT6 | ||
| Class IV | αY motif/THW motif/partial substrate pocket | 4X60, 4X61,4X63, 5EMJ, 5EMK, 5C9Z, 5EML, 5EMM | PRMT5 |
| Class V | Dimerization arm | 4RLY, 4QQN | PRMT3 |