Figure 5.

Effects of intravenous Triprolidine (1.0 and 3.0 mg/kg) administration on extracellular DA levels in dialysates from rats implanted with microdialysis probes in the NAc shell (filled circles) and core (filled squares). Note that though triprolidine shows very high affinity and selectivity for H1 receptors it does not modify dialysate DA levels from the shell or from the core. Results are means, with vertical bars representing SEM, of the amount of DA in 10-min dialysate samples, expressed as percentage of basal values. Basal DA values (fmoles/sample) and group size (n) were: 43.0 ± 2.3 (4), and 39.0 ± 7.7 (4) for 1 and 3 mg/kg groups in the NAc shell, and 43.3 ± 3.5 (4), and 41.0 ± 5.1 (4) for 1 and 3 mg/kg in the NAc core.