Figure 2:

Challenges with current neural interfaces. Mismatches in structural, mechanical, and topological features between the brain and interface lead to micromotion and a prolonged chronic immune response limiting the longevity of conventional neural recording probes⁶. Similarly, factors including the physical, chemical, and mechanical composition of the electrode influence probe features such as diameter, shape, cross-sectional area, and size of recording surfaces governing the spatial resolution of the interface^5,84. Mesh electronics optimize the neural interface design for structural, mechanical, and topological similarity between the implant and neural substrate in order to create an interface that “looks” and “feels” like the cellular and sub-cellular networks comprising the brain⁶².