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. 2019 Aug 29;55(4):879–895. doi: 10.3892/ijo.2019.4863

Figure 4.

Figure 4

PI3K/AKT signaling pathway serves an important role in glioblastoma multiforme. (A) The cluster heat map of expression patterns of upregulated and downregulated genes of CSC2078 after treatment with JQ1 as detected by RNA-Seq (upregulated, red; downregulated, green). (B) Different gene number of CSC2078 after JQ1 treatment vs. control. (C-F) Western blotting analysis expression of PI3K, AKT and p-AKT (Ser473) in control, JQ1-treated group and siBrd4 group (error bars represent standard error of the mean). (G and H) Western blotting analysis expression of p-AKT (Thr308) in CSC2078 cells treated with JQ1 (error bars represent standard error of the mean), *P<0.05, **P<0.01 vs. control. P, phosphorylated; siBrd4, small interfering RNA against bromodomain-containing protein 4.