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. 2019 Aug 29;55(4):879–895. doi: 10.3892/ijo.2019.4863

Figure 9.

Figure 9

Effects of JQ1 treatment on survival in glioblastoma multiforme. (A) The schematic showed the formation protocol of CSC2078 subcutaneous xenograft in nude mice for JQ1 or control experiment. (B) The images of tumor tissues resected from the control and JQ1 treatment groups. (C) Tumor volume quantification for CSC2078 xenografts in mice (n=5 mice for treatment group and control, error bars represent standard error of the mean). **P<0.01 vs. control. (D) Terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling staining of apoptotic cells in tumor samples as described in (B). Green, positive apoptosis cells. Scale bar=20 µm. (E) H&E staining of tumor tissues. Scale bar=20 µm. (F) Intratumoral molecular changes of tumor samples were detected using immunohistochemistry analysis. Scale bar=20 µm. BAX, Bcl-2-associated X protein; MMP, matrix metalloproteinase; PCNA, proliferating cell nuclear antigen.