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. 2019 Aug 27;55(4):805–822. doi: 10.3892/ijo.2019.4862

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Diagnostic ROC curves of key genes of JAK/STAT pathway using data from The Cancer Genome Atlas. ROC curves of JAK/STAT pathway members: (A) JAK1, (B) JAK2, (C) JAK3, (D) TYK2, (E) STAT1, (F) STAT2, (G) STAT3, (H) STAT4, (I) STAT5A, (J) STAT5B and (K) STAT6. ROC curves of combination of (L) JAK1 + 2, (M) JAK1 + STAT3, (N) JAK1 + TYK2, (O) JAK2 + STAT3, (P) JAK2 + TYK2, (Q) STAT3 + TYK2, (R) JAK1 + 2 + STAT3, (S) JAK1 + 2 + TYK2, (T) JAK1 + STAT3 + TYK2, (U) JAK2 + STAT3 + TYK2 and (V) JAK1 + 2 + STAT3 + TYK2. ROC, receiver operating characteristic; AUC, area under the curve; CI, confidence interval; JAK, Janus kinase; TYK2, tyrosine kinase 2; STAT, signal transducer and activator of transcription.