Table II.

Prognostic analysis of genes in JAK/STAT signaling pathway for overall survival in The Cancer Genome Atlas database.

Gene	Patients (n=370)	Overall survival
		No. of event	MST (days)	HR (95% CI)	Crude P-value	HR (95% CI)	Adjusted P-valuea
JAK1
Low expression	185	70	1,685	Ref.		Ref.
High expression	185	60	2,116	0.790 (0.557-1.119)	0.184	0.542 (0.364-0.807)	0.003b
JAK2
Low expression	185	69	1,622	Ref.		Ref.
High expression	185	61	2,116	0.781 (0.552-1.105)	0.163	0.574 (0.388-0.848)	0.005b
JAK3
Low expression	185	69	1,622	Ref.		Ref.
High expression	185	61	1,694	0.859 (0.609-1.213)	0.389	0.816 (0.551-1.208)	0.310
TYK2
Low expression	185	69	1,490	Ref.		Ref.
High expression	185	61	2,456	0.824 (0.583-1.165)	0.274	0.799 (0.541-1.180)	0.260
STAT1
Low expression	185	69	1,694	Ref.		Ref.
High expression	185	61	1,685	0.874 (0.618-1.237)	0.448	0.909 (0.609-1.358)	0.641
STAT2
Low expression	185	70	1,423	Ref.		Ref.
High expression	185	60	2,486	0.744 (0.526-1.053)	0.095	0.715 (0.481-1.063)	0.098
STAT3
Low expression	185	68	1,622	Ref.		Ref.
High expression	185	62	2,116	0.851 (0.602-1.203)	0.360	0.727 (0.495-1.069)	0.105
STAT4
Low expression	185	73	1,423	Ref.		Ref.
High expression	185	57	2,486	0.693 (0.490-0.981)	0.038b	0.730 (0.487-1.095)	0.128
STAT5A
Low expression	185	72	1,147	Ref.		Ref.
High expression	185	58	2,456	0.626 (0.442-0.888)	0.009b	0.648 (0.435-0.967)	0.033b
STAT5B
Low expression	185	78	1,271	Ref.		Ref.
High expression	185	52	2,456	0.594 (0.418-0.845)	0.004b	0.604 (0.408-0.895)	0.012b
STAT6
Low expression	185	75	1,372	Ref.		Ref.
High expression	185	55	2,456	0.594 (0.418-0.843)	0.004b	0.531 (0.357-0.790)	0.002b

^aP-values were adjusted for radical resection, tumor stage and hepatitis B infection;

^bsignificant P-values and 95% CI. JAK, Janus kinase; STAT, signal transducer and activator of transcription; NA, not available; MST, median survival time; HR, hazard ratio; 95% CI, 95% confidence interval; Ref., reference; TYK2, tyrosine kinase 2.