Table V.
Risk score model construction of genes in GSE14520 dataset and TCGA database.
| A, GSE14520
| |||||
|---|---|---|---|---|---|
| Variable | β | SE | Wald | HR (95% CI) | P-value |
| Tumor size | 0.038 | 0.269 | 0.020 | 1.039 (0.613-1.761) | 0.886 |
| Cirrhosis | −1.072 | 0.736 | 2.122 | 0.342 (0.081-1.448) | 0.145 |
| BCLC stage | |||||
| 0 | 28.571 | <0.0001 | |||
| A | 1.440 | 0.726 | 3.938 | 4.223 (1.018-17.518) | 0.047 |
| B | 1.828 | 0.789 | 5.362 | 6.219 (1.324-29.209) | 0.021 |
| C | 2.976 | 0.780 | 14.551 | 19.612 (4.25-90.496) | 0.0001 |
| AFP | 0.194 | 0.230 | 0.717 | 1.214 (0.774-1.904) | 0.397 |
| JAK2 | −0.500 | 0.239 | 4.398 | 0.606 (0.380-0.968) | 0.036 |
| STAT5A | −0.592 | 0.239 | 6.127 | 0.553 (0.346-0.884) | 0.013 |
| STAT6 | −0.616 | 0.231 | 7.101 | 0.540 (0.343-0.850) | 0.008 |
|
B, TCGA | |||||
| Variable | β | SE | Wald | HR (95% CI) | P-value |
|
| |||||
| Tumor stage | |||||
| I | 8.832 | 0.012 | |||
| II | 0.249 | 0.265 | 0.881 | 1.283 (0.763-2.159) | 0.348 |
| III + IV | 0.669 | 0.227 | 8.673 | 1.952 (1.251-3.045) | 0.003 |
| Radical resection | 0.266 | 0.360 | 0.548 | 1.305 (0.645-2.642) | 0.459 |
| HBV infection | −0.854 | 0.266 | 10.305 | 0.426 (0.253-0.717) | 0.001 |
| JAK2 | −0.567 | 0.200 | 8.045 | 0.567 (0.383-0.839) | 0.005 |
| STAT5A | −0.320 | 0.206 | 2.405 | 0.726 (0.485-1.088) | 0.121 |
| STAT6 | −0.631 | 0.205 | 9.507 | 0.532 (0.356-0.795) | 0.002 |
TCGA, The Cancer Genome Atlas; SE, standard error; HR, hazard ratio; 95% CI, 95% confidence interval; BCLC, Barcelona Clinic Liver Cancer; HBV, hepatitis B virus; JAK2, Janus kinase 2; STAT, signal transducer and activator of transcription.