Fig 4. Simulation study: Specificity of extraction methods and mapping on COSMIC signatures as the number of analysed catalogues and the cosine cut-off h vary.

Specificity is estimated from 50 replicates each made of G genomes. The average number of mutations in each catalogue is r = 10,000. The model used to simulate realistic replicates according to the four Profiles and the estimation methods are described in the section Data and experimental settings.