Table 1.
Summary of ERG parameters
| Genotype | bmax, scot(μV) | I0.5 (scotopic cd-sec/m2) | amax (μV) | k × A (sec−2 (scotopic cd-sec m−2)−1) | bmax, phot(μV) |
|---|---|---|---|---|---|
| +/+ | 650 ± 18 (n = 4) | (16.3 ± 2.3) × 10−4 | 580 ± 130 | 3340 ± 950 | 180 ± 30 (n = 5) |
| +/− | 675 ± 11 (n = 5) | (17.6 ± 1.3) × 10−4 | 620 ± 60 | 4040 ± 1030 | 200 ± 70 (n = 4) |
| −/− | 335 ± 8 (n = 5) | (120.3 ± 10.5) × 10−4 | 285 ± 60 | 3100 ± 375 | 65 ± 25 (n = 5) |
| −/−, 9 months | 0 (n = 3) | 0 | 0 |
The first column indicates the genotype of the BETA2/NeuroD mice. The parameter bmax,scot represents the saturating amplitude of the scotopic b wave, andI0.5 is the intensity, measured as scotopic cd-sec/m2, which produces one-half ofbmax,scot (see Materials and Methods). The value shown in the table represents the best fit, and the second number is the error of the fit. For the remaining parameters, the first value represents the mean and the second value represents the SE. The parameter amax is the amplitude of the a wave in response to an intense, saturating flash measured to produce 2.97 log scotopic cd-sec/m2. The parameter k × Awas obtained by fitting the a wave using the model developed byLamb and Pugh (1992) and modified by Hood and Birch (1994). Isolated cone responses were measured using the paired-flash technique (see experimental procedures in Lyubarsky et al., 1999). bmax,phot measures the peak amplitude of the filtered b wave in response to a flash that produces 143 photopic cd-sec/m2.