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. 2003 Jan 15;23(2):392–402. doi: 10.1523/JNEUROSCI.23-02-00392.2003

Fig. 1.

Fig. 1.

Schematic and nomenclature of β-dystroglycan and CD8 variants. A, Full-length β-dystroglycan (S654–P895) is represented by DG. Variant nomenclature is as follows: ΔP, C-terminal deletion;tm, transmembrane domain; O, outside;I, inside; J, juxtamembrane. All mutants have an N-terminal HA epitope that is preceded in frame by the N-terminal-cleaved signal sequence derived from prolactin (data not shown). The C-terminal dystrophin/utrophin/Grb2-binding motif is indicated by single-letter amino acid code (PPXY). ecto, Ectodomain. B, Amino acid sequence alignment of dystroglycan (amino acids 746–782) and CD8 transmembrane (amino acids 189–225) and juxtamembrane deletion mutants. Alignment of CD8 variants with dystroglycan variants is based on the cytoplasmic juxtamembrane sequence (ICY). Dystroglycan residues are in bold.