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Membrane-permeant cGMP analogs also increase baseline firing rate. A, Example traces from one neuron in control and 35 min after application of 50 μm8p-CPT-cGMP. Calibration: 30 pA, 100 msec. B, Average, normalized firing rate versus time for 10 Purkinje neurons. After a 10 min control period, 50 μm 8p-CPT-cGMP was added at the indicated time. On average, the firing rate increased 17.7 ± 4.1%.
