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a, Changes in spontaneous synaptic currents in WT and R6/2 mice from 3–4 weeks to 11–15 weeks. Note the occurrence of the large event in the transgenic at 5–7 weeks (arrow). b, CNQX (applied atarrow) almost completely abolished spontaneous synaptic activity (WT, 81 d). Traces below and abovesolid and dashed lines are magnified to more clearly see the effects of CNQX. In this and other figures, all neurons were held at −70 mV.
