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. 2003 Feb 1;23(3):961–969. doi: 10.1523/JNEUROSCI.23-03-00961.2003

Fig. 6.

Fig. 6.

a, Addition of BIC and 4-AP to the ACSF solution increased the frequency and amplitudes of the EPSCs, including the large events in both WT and R6/2 (comparemiddle and top traces). Riluzole reduced the frequency of EPSCs and blocked almost completely the large events (bottom traces). b, Mean frequency of total (left) and large (right) events in ACSF (Control) in BIC and 4-AP and the decrease produced by riluzole. There were statistically significant decreases in the frequency of total events in all age groups of R6/2 transgenics compared with controls. Although BIC and 4-AP also increased the frequency of large events (>100 pA) and riluzole decreased the frequency of these events, only the difference in the control condition was statistically significant.