Fig. 5.

Mapping links between cognitive performance and changing brain structure. These maps show the significance of the linkage between gray matter reductions and cognition, as measured by MMSE score. Variations in temporal, parietal, and ultimately frontal (e) tissue are linked with cognitive status. Less gray matter is strongly correlated with worse cognitive performance, in all regions with prominent deficits. Linkages are detected most strongly in the left hemisphere medial temporoparietal zones (d). As expected, no linkages are found with sensorimotor gray matter variation (b), which was not in significant deficit in late AD.