Fig. 5.

Reversal of perisciatic SIN-induced mechanical allodynias by intrathecal anti-rat IL6, 1 d later. Rats were assessed for low-threshold mechanical sensitivity (von Frey test) both before (baseline) and 13, 15, 17, and 19 hr after completion of perisciatic drug administration. Replicating experiment 3 and extending our earlier studies (Chacur et al., 2001; Gazda et al., 2001), low-dose zymosan induced a unilateral allodynia (A), whereas high-dose zymosan induced a bilateral allodynia (B) at 13 hr after injection. Both were reversed by intrathecal anti-rat IL6 at this time, whereas anti-IL6 had no effect on behavior in the absence of perisciatic zymosan (A).