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. 2003 Mar 1;23(5):1974–1980. doi: 10.1523/JNEUROSCI.23-05-01974.2003

Fig. 3.

Fig. 3.

Evoked overflow of dopamine in the basal ganglia of aged rhesus monkeys chronically treated with GDNF or vehicle. Excess potassium (100 mm) was included in the perfusate for 30 min starting at 0 min (horizontal bar above K+), and 250 μmd-amphetamine (AMPH) was included in the perfusate for 30 min starting at 120 min (horizontal bar above AMPH). Both potassium-evoked and d-amphetamine-induced overflow of dopamine in the substantia nigra (A, B), caudate nucleus (C), and putamen (D) were significantly increased in the GDNF recipients compared with the vehicle recipients. The values shown are means ± SEM. *p < 0.05 versus vehicle group at same time point.