Fig. 2.

Bar graph shows the result of the unbiased stereological calculation of spine synapse density in the stratum radiatum of the CA1 subfield of control, gonadectomized (GDX), gonadectomized plus testosterone-treated (GDX+T), gonadectomized plus dihydrotesterone-treated (GDX+DHT), and gonadectomized plus estrogen-treated (GDX+E2) male rats. There is no significant difference between the density values of spine synapses between the Control, GDX+T, andGDX+DHT animals. However, the spine synapse density of the GDX and GDX+E2 rats is significantly (p < 0.001) lower (48%) than that of control animals.