Table 2.
Pharmacological characterization of glutamate uptake into spinal cord synaptosomes prepared from transgenic G93A rats and age-matched controls
| PDC (μm) | DHK (μm) | |
|---|---|---|
| End stage | ||
| CON | 1.4 ± 0.1 | 74.2 ± 6.0 |
| G93A | 1.8 ± 0.1 | 75.3 ± 0.9 |
| Onset | ||
| CON | 1.6 ± 0.3 | 98.2 ± 5.3 |
| G93A | 2.4 ± 0.1 | 79.9 ± 8.1 |
| Presymptomatic | ||
| CON | 2.4 ± 0.5 | 87.9 ± 3.2 |
| G93A | 2.3 ± 0.3 | 89.8 ± 13.1 |
Pharmacological sensitivity of glutamate uptake in synaptosome fractions prepared from spinal cord of G93A and age-matched control (CON) rats was evaluated at various stages of disease progression. IC50 values were generated by nonlinear regression analysis of log concentration–response curves using the four-parameter logistic model. Data are mean ± SEM values from three independent experiments.