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. 2003 Mar 15;23(6):2193–2202. doi: 10.1523/JNEUROSCI.23-06-02193.2003

Fig. 2.

Fig. 2.

Immunostaining of HD mouse striatum.A, The striatum of N171-82Q (4 months old), HdhCAG150 knock-in (14 months old), R6/1 (8 months old), and R6/2 (3 months old) mice were stained with EM48, which specifically reacts with mutant huntingtin and its aggregates. Note that both nuclear inclusions and neuropil aggregates are present in all of the HD mouse brains examined, although they are more abundant in R6/2 and R6/1 mice.B, The striatum of HdhCAG150 was also labeled by the antibody EM121, which reacts with huntingtin amino acids 359–429. Only diffuse cytoplasmic staining was seen in HD mice, with a pattern similar to that of the wild-type (WT) mice. Scale bar, 10.8 μm.