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. 2003 Apr 1;23(7):2899–2910. doi: 10.1523/JNEUROSCI.23-07-02899.2003

Fig. 7.

Fig. 7.

Effects of riluzole on the induction of thermal hyperalgesia and mechanical allodynia after CCI. Intraperitoneal treatment with 1 or 4 mg/kg riluzole (RIL-1 orRIL-4) twice daily for postoperative days 1–4 beginning immediately after the operation significantly reduced the development of thermal hyperalgesia (A) and mechanical allodynia (B). Note that the effects of riluzole on thermal hyperalgesia and mechanical allodynia lasted at least several days after its discontinuation on postoperative day 5, indicating a significant role of regulating GT uptake activity in the development of neuropathic pain behaviors in CCI rats. The effect of riluzole on thermal hyperalgesia was dose-dependent. *p < 0.05 and **p < 0.01 as compared with CCI rats treated with vehicle (CCI+VEH); +p < 0.05 as compared with the low dose (1 mg/kg) riluzole group. ForDiff. score, see Figure 4.