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. 2003 Apr 1;23(7):2899–2910. doi: 10.1523/JNEUROSCI.23-07-02899.2003

Fig. 8.

Fig. 8.

Effects of riluzole on the maintenance of thermal hyperalgesia and mechanical allodynia after CCI. Intraperitoneal treatment with 1 or 4 mg/kg riluzole (RIL-1 orRIL-4) twice daily for 4 d beginning on postoperative day 5 gradually reversed thermal hyperalgesia (A) and mechanical allodynia (B) when rats were examined on postoperative days 8 and 10. *p < 0.05 and **p < 0.01 as compared with CCI rats treated with vehicle (CCI+VEH); +p < 0.05 as compared with the low dose (1 mg/kg) riluzole group.Arrows indicate the beginning of the riluzole treatment on postoperative day 5. For Diff. score, see Figure4.